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HoneyGuard-R Liquid is an innovative RNA interference (RNAi)-based biopesticide designed to protect honeybees from the deadly Sacbrood Virus (SBV). By targeting and suppressing viral replication at the genetic level, it drastically reduces colony mortality without leaving harmful chemical residues. Safe for bees, humans, and the ecosystem, HoneyGuard-R Liquid provides beekeepers with a sustainable, eco-friendly solution to safeguard hive health and ensure global agricultural pollination.

Honey Guard-R Solution

Protect the Colony Before Sacbrood Spreads

  • Harnessing Nature’s Defense Through Advanced RNA Science
  • Targeted RNAi-Based Protection Against Sacbrood Disease

HoneyGuard-R Solution is an RNA interference (RNAi)-based veterinary medicinal product approved in the Republic of Korea for the prevention and treatment of sacbrood disease caused by Korean sacbrood virus (KSBV) in honeybees.

Its active ingredient, double-stranded RNA (dsRNA), is designed to target a specific sequence within KSBV RNA. When administered orally after being mixed with sugar syrup, the dsRNA is processed by the RNAi pathway in honeybees, enabling the sequence-specific recognition, cleavage, and degradation of the target viral RNA.

This target-specific action helps suppress viral replication, protect honeybee colonies against sacbrood disease, and support colony health

Commercialized under Licensed APQA patented technology by Genolution Inc. Patent no. 10-2317631

[1. INGREDIENTS AND QUANTITIES] (Per 1 L)
– Active Ingredient: Double-stranded RNA complementary to the coat protein transcription sequence of Korean Sacbrood Virus (GN01) (Separate Specification) – 1 g
– Excipient: Purified Water – Q.S.

[2. INDICATIONS AND EFFECTS]
Prevention of Korean Sacbrood Virus (KSBV) in Honeybees
A. Honeybees: Prevention of viral Korean Sacbrood Disease.

[3. DOSAGE AND ADMINISTRATION]
Honeybees: Administer orally 20 mg of the active ingredient per bee colony daily for 1 day.
A) Dosage: Mix 20 mL of this product thoroughly with 280 mL of sugar syrup (feeding solution) and administer orally.
B) Method: Administer 3 times biweekly during spring and autumn seasons.

[4. STORAGE AND EXPIRATION DATE]
A. Storage Condition: Store at room temperature (1-30°C), protected from direct sunlight.
B. Container Type: Airtight container.
C. Shelf Life: 24 months from the date of manufacture.

[5. PRECAUTIONS FOR USE]
A. General Precautions
1) This is a veterinary medicinal product. Do NOT use on humans under any circumstances.
2) Safety and efficacy have not been established for animals other than the specified target species; do not use arbitrarily.
3) Strictly adhere to the prescribed dosage and administration instructions to prevent accidents caused by misuse/overuse and residue contamination in livestock foods.
4) Do not co-administer drugs with identical active ingredients, nor mix this product with other pharmaceuticals.
5) Once diluted in drinking water/feeding solution, use as soon as possible. Discard any leftover solution and do not reuse.

B. Operator / Handling Precautions
1) Handlers must wear protective equipment including gloves, mask, and protective clothing to avoid direct skin contact or inhalation.
2) Wash hands and body thoroughly after handling this product.

C. Withdrawal Period: Not Applicable (N/A)
(However, the following instructions MUST be strictly observed when using this product)
1) Do NOT use during the honey-flow season (nectar collection period).
2) Honey produced from bee colonies managed with this product during spring and autumn must be discarded (cleared) and must NOT be used for human consumption.

D. Storage Precautions
1) Keep out of reach of children and animals to prevent safety accidents.
2) Comply with specified storage conditions, as improper storage may cause changes in efficacy and stability.
3) Do not use expired products; dispose of them safely.
4) After opening, use as quickly as possible. Keep unused portions sealed in the original container and store in a cool place protected from light and moisture.
5) Safely dispose of empty containers/packaging materials; do not reuse them for other purposes.

E. Additional Instructions
1) Read the product package insert thoroughly before use.
2) Use under the direction of a veterinarian.
3) Keep detailed administration logs to prevent drug misuse, overuse, and antimicrobial/antiviral resistance.
4) For further product inquiries, contact the applicant or manufacturer.

[ 1. Why Honeyguard-R ]
[ 2. How it works ]
[ 3. How to use ]
Specification

ACTIVE INGREDIENT
dsRNA · 1 g/L
dsRNA targeting a specific KSBV RNA sequence

SCHEDULE
3 Applications
At 2-week intervals in early spring and autumn, before overwintering (based on seasonal conditions in Korea).

DOSAGE
20 mL per Colony
Mix 20 mL of HoneyGuard-R Solution with 280 mL of sugar syrup.

STORAGE
1–30°C
Protect from direct sunlight. Do not store or reuse any remaining prepared solution.

ADMINISTRATION
Oral Feeding
Administer the prepared solution using a feeder bag placed inside the hive.

SHELF LIFE
24 Months
From the date of manufacture

Pipetting Method
Air displacemen

Technical parameter
Power : 100 - 240 VAC, 50/60 Hz
Heating range : 5 ~ 40 °C
UV sterilizatio

Maximun Pipetting Range
250 μl

Sample barcode reading capability
yes